SAMHSA's Partnerships for Success (PFS) I grant program provides eligible states and jurisdictions with funds to achieve quantifiable declines in state-wide substance abuse rates. The overall goals of PFS I are as follows: (1) reduce substance abuse-related problems; (2) prevent the onset and reduce the progression of substance abuse, including childhood and underage drinking; strengthen capacity and infrastructure at the State- and community-levels in support of prevention; and leverage, redirect, and realign State-wide funding streams for prevention. Only states that have received a Cohort I or II Strategic Prevention Framework State Incentive Grant (SPF SIG) are eligible.

In 2012, SAMHSA announced the PFS II grant program, which is designed to address two of the nation's top substance abuse prevention priorities: (1) underage drinking among individuals ages 12 to 20, and (2) prescription drug misuse and abuse among individuals ages 12 to 25. The PFS II provides additional resources to states for implementing the SPF process at the state and community levels and promotes the alignment and leveraging of prevention resources and priorities at the federal, state, and community levels. Only Cohort I, II, or III SPF SIG recipients who are currently not receiving funds through PFS I are eligible.